Umbelliprenin Mediates Its Apoptotic Effect by Hormesis: A Commentary

Umbelliprenin Mediates Its Apoptotic Effect by Hormesis: A Commentary

Despite common dose–response curves, a compound may have the opposite effect in small doses as in large doses. This phenomenon is named hormesis. Calabrese et al have reported that many toxic substances, environmental hormones, inorganic compounds, and even irradiation induce hormesis. They modulate the growth of cultured cells in a biphasic fashion, either stimulating or inhibiting the growth ...

Phytotchemical phytotoxins and hormesis - a commentary.

Chloramphenicol, European legislation and hormesis commentary.

Zinc mediates the neuronal activity–dependent anti-apoptotic effect

Synaptic activity increases the resistance of neurons to diverse apoptotic insults; however, the underlying mechanisms remain less well understood. Zinc promotes cell survival under varied conditions, but the role of synaptically released zinc in the activity-dependent anti-apoptotic effect is unknown. Using cultured hippocampal slices and primary neurons we show that a typical apoptosis induce...

Umbelliprenin, a bioactive constituent from the genus Ferula has cytotoxic and apoptotic activity in a dose- and time-dependent manner